abstract：OBJECTIVE:The goal of this study was to determine the frequencies of important allelic variants of two drug targets, dipeptidyl carboxypeptidase ( DCP1) and cholesteryl ester transfer protein ( CETP), and two other drug receptors, beta-2 adrenergic receptor ( ADRB2) and 5-hydroxy tryptamine 2A receptor ( HTR2A), in the...

journal_title：European journal of clinical pharmacology

authors： Hamdy SI,Hiratsuka M,Narahara K,El-Enany M,Moursi N,Ahmed MS,Mizugaki M

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVES:Problem-oriented drug information is characterised by health professionals actively seeking drug information through various sources. In this study our objective was to determine the quality and impact of problem-oriented drug information among physicians. METHODS:Evaluation forms accompanying 163 written a...

journal_title：European journal of clinical pharmacology

authors： Schjøtt J,Pomp E,Gedde-Dahl A

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVE:To investigate the influence of concomitant administration of roxithromycin on the plasma pharmacokinetics of lovastatin. METHODS:In an open, randomized, crossover study, 12 healthy volunteers received 80 mg lovastatin orally either alone or concomitantly with 300 mg roxithromycin after 5-day pretreatment wi...

journal_title：European journal of clinical pharmacology

authors： Bucher M,Mair G,Kees F

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:The aim of this investigation was to clarify the stereoselective properties in lansoprazole metabolism by monitoring the metabolic consumption for each enantiomer and the formation of the main metabolites, lansoprazole sulfone and 5-hydroxylansoprazole, in the presence of human liver microsomal enzymes. METH...

journal_title：European journal of clinical pharmacology

authors： Katsuki H,Hamada A,Nakamura C,Arimori K,Nakano M

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVE:Use of analgesic drugs in acute renal colic varies widely in different countries. In order to assess the prescribing patterns in acute renal colic in French emergency departments (EDs), the present study compared intentions of prescription, real prescription and evidence-based data in a sample of emergency pr...

journal_title：European journal of clinical pharmacology

authors： Jean R,Ducasse JL,Montastruc JL,Lapeyre-Mestre M

更新日期：2001-11-01 00:00:00

abstract：:The most convenient route of drug administration is peroral. To reach their target, drug molecules must be absorbed from the gastrointestinal tract and enter the systemic circulation in sufficient quantities. For this reason, understanding and anticipating the mechanisms and factors affecting gastrointestinal absorpti...

journal_title：European journal of clinical pharmacology

authors： Pelkonen O,Boobis AR,Gundert-Remy U,Action COST B15 Working Group 1.

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:Databases of subjects receiving antidepressants provide evidence on the use of drugs in typical patients and settings under real-world conditions. This study analysed a general practice database to estimate the prevalence of antidepressant drug use, describe the use of these compounds by gender and age and es...

journal_title：European journal of clinical pharmacology

authors： Pietraru C,Barbui C,Poggio L,Tognoni G

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:Psychotropic drug use among nursing home residents with regard to diagnostic indications and patient- and institution characteristics was analysed. METHODS:A cross-sectional study of medication data from 1552 residents at 23 nursing homes in Bergen, Norway, was performed. Psychotropic drug use (neuroleptics,...

journal_title：European journal of clinical pharmacology

authors： Ruths S,Straand J,Nygaard HA

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:We previously found that, compared with healthy subjects. asymptomatic hepatitis-B virus (HBV) carriers displaying slow acetylator phenotype demonstrate a significant prolongation of the elimination half-life of 4-methylaminoantipyrine (MAA) and a decrease in the clearance of formation of 4-aminoantipyrine (A...

journal_title：European journal of clinical pharmacology

authors： Levy M,Safadi R,Zylber-Katz E,Granit L,Caraco Y

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to describe determinants of current and subsequent benzodiazepine use in an elderly population, the Paquid cohort. METHODS:The study was conducted on a cohort of 2,792 community-dwelling subjects 65 years of age or more living in the Gironde department, southwestern France. B...

journal_title：European journal of clinical pharmacology

authors： Fourrier A,Letenneur L,Dartigues JF,Moore N,Bégaud B

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Fexofenadine is the active metabolite of the non-sedating anti-histamine terfenadine. Pre-licensing clinical trials in over 6000 patients suggested it was effective and well tolerated. OBJECTIVE:To assess the tolerability and safety of fexofenadine immediately after its availability on the UK market in Marc...

journal_title：European journal of clinical pharmacology

authors： Craig-McFeely PM,Acharya NV,Shakir SA

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to define the pharmacokinetic profile of free carbamazepine (F-CBZ) in adult Omani epileptic patients in order to improve on dosing schedules through population pharmacokinetic analysis using the NONMEM program. METHOD:Steady-state trough F-CBZ serum concentrations, carbamazepine (C...

journal_title：European journal of clinical pharmacology

authors： Deleu D,Aarons L,Ahmed IA

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:To investigate whether an association between the use of selective serotonin reuptake inhibitor (SSRI) antidepressants and abnormal bleeding is demonstrated in a large population study. METHODS:An observational cohort study using cohorts from the Drug Safety Research Unit's prescription event monitoring data...

journal_title：European journal of clinical pharmacology

authors： Layton D,Clark DW,Pearce GL,Shakir SA

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVES:To investigate whether treatment with acarbose alters the pharmacokinetics (PK) of coadministered rosiglitazone. METHODS:Sixteen healthy volunteers (24-59-years old) received a single 8-mg dose of rosiglitazone on day 1, followed by 7 days of repeat dosing with acarbose [100 mg three times daily (t.i.d.) wi...

journal_title：European journal of clinical pharmacology

authors： Miller AK,Inglis AM,Culkin KT,Jorkasky DK,Freed MI

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:Withdrawal of a drug from the market for safety reasons is a serious and sometimes complex decision. The scientific evidence supporting drug withdrawals in the past years is critically appraised. METHODS:With data provided by the Spanish Medicines Agency, all drugs withdrawn from the Spanish market for safet...

journal_title：European journal of clinical pharmacology

authors： Arnaiz JA,Carné X,Riba N,Codina C,Ribas J,Trilla A

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:To search for ethnic variability in the impact of cytochrome P450 2C9 (CYP2C9) polymorphism. METHODS:CYP2C9 allelic variants related to impaired CYP2C9 metabolism were analysed in genomic DNA from 157 Spanish healthy subjects using amplification-restriction and sequencing procedures. RESULTS:The frequency f...

journal_title：European journal of clinical pharmacology

authors： García-Martín E,Martínez C,Ladero JM,Gamito FJ,Agúndez JA

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:To assess the initial uptake in use and co-prescribing patterns of sildenafil. METHODS:We examined prescription details of the Eastern Health Board Region (including Dublin) of the General Medical Services (GMS) in Ireland, which provides detail on prescriptions dispensed in primary care for this population ...

journal_title：European journal of clinical pharmacology

authors： Williams D,Feely J

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:To assess the pharmacokinetics, safety and tolerability of escalating oral doses of GW420867X, a non-nucleoside reverse transcriptase inhibitor, was investigated in healthy male volunteers in a randomized, double-blind placebo-controlled study. METHODS:Study subjects were divided into four groups of 12 subje...

journal_title：European journal of clinical pharmacology

authors： Moore KH,Cass LM,Dallow N,Hardman TC,Jones A,Boyce M,Prince WT

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:To study the effects of possible interactions between levosimendan and warfarin on pharmacokinetics and pharmacodynamics. Furthermore, the effects of levosimendan on blood coagulation were investigated. METHODS:Open, randomised cross-over design with two treatment phases was used. During one phase, levosimen...

journal_title：European journal of clinical pharmacology

authors： Antila S,Jarvinen A,Honkanen T,Lehtonen L

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVES:To assess relative roles of the intestinal and hepatic stereoselective metabolism of nicardipine in an oral first-pass disposal with and without grapefruit juice intake. METHODS:The kinetic profiles of (+)- and (-)-nicardipine were studied in the six normal healthy male volunteers who received oral (40 mg) ...

journal_title：European journal of clinical pharmacology

authors： Uno T,Ohkubo T,Sugawara K,Higashiyama A,Motomura S,Ishizaki T

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVES:To study the frequency of corticosteroid therapy and the use of inpatient care for preschool children with wheezing in two regions in Finland. METHODS:The Finnish Social Insurance Institution database on refundable asthma medication indicated that 1.18% of children in Tampere and 2.37% in Turku used inhaled...

journal_title：European journal of clinical pharmacology

authors： Csonka P,Mertsola J,Klaukka T,Kaila M,Ståhlberg MR,Ashorn P

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:The aim of this investigation was to determine whether mefenamic acid and salicylic acid inhibit the sulfation of (-)-salbutamol and minoxidil in the human liver and duodenum, and if so, to ascertain whether the 50% inhibitory concentration (IC50) estimates are different in the two tissues. METHODS:Sulfotran...

journal_title：European journal of clinical pharmacology

authors： Vietri M,Pietrabissa A,Spisni R,Mosca F,Pacifici GM

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE/METHODS:The metabolism of chloramphenicol succinate (CAPS) by human bone marrow was studied in vitro using 75 marrow samples. Whole marrow samples were incubated with CAPS with or without reduced nicotinamide adenine dinucleotide phosphate for 1, 2 and 3 h at 37 degrees C. Ficoll-paque-separated marrow mononu...

journal_title：European journal of clinical pharmacology

authors： Ambekar CS,Cheung B,Lee J,Chan LC,Liang R,Kumana CR

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVES:To compare 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) as substrates for the methylation reaction catalysed by the enzyme thiopurine S-methyltransferase (TPMT). METHODS:TPMT activity in haemolysed red blood cells of healthy blood donors was determined twice, using the same experimental setting and equa...

journal_title：European journal of clinical pharmacology

authors： Kröplin T,Iven H

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy of activated charcoal and gastric lavage in preventing the absorption of moclobemide, temazepam, and verapamil 30 min after drug ingestion. METHODS:In this randomized cross-over study with three phases, nine healthy volunteers received a single oral dose of 150 mg moclobemide, 10 mg t...

journal_title：European journal of clinical pharmacology

authors： Lapatto-Reiniluoto O,Kivistö KT,Neuvonen PJ

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:To determine the pharmacokinetics and organ distribution of i.v. and oral methylene blue, which is used to prevent ifosfamide-induced encephalopathy in oncology. METHODS:The concentration of methylene blue in whole blood was measured using high-performance liquid chromatography in seven volunteers after i.v....

journal_title：European journal of clinical pharmacology

authors： Peter C,Hongwan D,Küpfer A,Lauterburg BH

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVES:Caffeine-containing beverages are generally consumed by Nigerians suffering from malaria and kwashiorkor in the belief that caffeine aids early recovery from these illnesses, which are common in the tropics. However, there are no studies on the influence of these diseases on the absorption and pharmacokineti...

journal_title：European journal of clinical pharmacology

authors： Akinyinka OO,Sowunmi A,Honeywell R,Renwick AG

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVES:Evidence exists to suggest that diclofenac is metabolised by CYP2C9. The present study was undertaken in order to evaluate the effect of the single CYP2C9*3 variant on drug metabolism using diclofenac as a probe drug. METHODS:A single dose of diclofenac was administered orally to 12 healthy subjects in whom...

journal_title：European journal of clinical pharmacology

authors： Shimamoto J,Ieiri I,Urae A,Kimura M,Irie S,Kubota T,Chiba K,Ishizaki T,Otsubo K,Higuchi S

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to clarify the effect of genetic polymorphisms of CYP2C19 on the pharmacokinetics of phenobarbitone (PB) using a nonlinear mixed-effects model (NONMEM) analysis in Japanese adults with epilepsy. METHODS:A total of 144 serum PB concentrations were obtained from 74 subjects treated wi...

journal_title：European journal of clinical pharmacology

authors： Mamiya K,Hadama A,Yukawa E,Ieiri I,Otsubo K,Ninomiya H,Tashiro N,Higuchi S

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVE:In animal studies, it has been shown that verapamil reduces strength and endurance of the diaphragm and inhibits the beneficial effects of theophylline. We examined whether the use of verapamil in patients with severe chronic obstructive pulmonary disease (COPD) who use theophylline leads to a deterioration o...

journal_title：European journal of clinical pharmacology

authors： Broeders ME,Heijdra YF,Smits P,Folgering HT,Kramers C

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:To describe the epidemiology of psychotropic drug use in a sample of Italian outpatient psychiatric services. METHODS:Drug-utilisation survey conducted within the framework of a broader prospective follow-up study with 67 Italian outpatient psychiatric services. RESULTS:The data concern 2322 patients recrui...

journal_title：European journal of clinical pharmacology

authors： Tognoni G

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:The extrapolated area under the concentration-time curve (AUC0-infinity) for any drug is considered by operating guidelines as the primary parameter related to the extent of absorption in single-dose bioavailability and bioequivalence trials. Not more than 20% should be added to the experimental AUC (AUC0-t) ...

journal_title：European journal of clinical pharmacology

authors： Marzo A,Monti NC,Vuksic D

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVES:To assess (1) whether the utilisation of codeine or propoxyphene differs among the three major Swedish cities (Stockholm, Göteborg and Malmö) and between urban and semirural areas; (2) if so, whether it co-varies with the utilisation of other potentially dependence-promoting drugs, benzodiazepines; (3) what ...

journal_title：European journal of clinical pharmacology

authors： Henricson K,Carlsten A,Ranstam J,Rametsteiner G,Stenberg P,Wessling A,Melander A

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVES:To evaluate the dose-response relationship of increasing doses of oxymetazoline compared with placebo in normal subjects, and to determine the sensitivities of rhinomanometry, acoustic rhinometry and symptoms in discriminating between differing doses of oxymetazoline in normal subjects. METHODS:The study ha...

journal_title：European journal of clinical pharmacology

authors： Taverner D,Bickford L,Shakib S,Tonkin A

更新日期：1999-09-01 00:00:00

abstract：OBJECTIVE:Entacapone is a peripherally acting catechol O-methyltransferase (COMT) inhibitor used as an adjunct to each daily levodopa/dopa decarboxylase (DDC) inhibitor dose in the treatment of Parkinson's disease. Parkinsonian patients with advanced disease and motor fluctuations take several doses of levodopa daily, ...

journal_title：European journal of clinical pharmacology

authors： Rouru J,Gordin A,Huupponen R,Huhtala S,Savontaus E,Korpela K,Reinikainen K,Scheinin M

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVE:As quinine is mainly metabolised by human liver CYP3A4 and grapefruit juice inhibits CYP3A4, the effect of grapefruit juice on the pharmacokinetics of quinine following a single oral dose of 600 mg quinine sulphate was investigated. METHODS:The study was carried out in ten healthy volunteers using a randomis...

journal_title：European journal of clinical pharmacology

authors： Ho PC,Chalcroft SC,Coville PF,Wanwimolruk S

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:Losartan was given to subjects with known phenotypes of the polymorphic enzymes CYP2D6 and CYP2C19 to study any possible influence on the metabolism of the drug. METHODS:Plasma concentrations of losartan and E-3174 were studied after oral intake of 50 mg losartan in 24 healthy, male, Swedish Caucasian subjec...

journal_title：European journal of clinical pharmacology

authors： Sandwall P,Lo MW,Jonzon B,Dalén P,Furtek C,Ritter M,Alván G,McCrea J,Sjöqvist F

更新日期：1999-06-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy and safety of repaglinide, a novel oral prandial glucose regulator, with that of glibenclamide, an oral hypoglycaemic agent, in the treatment of patients with type 2 diabetes. METHODS:This was a 14-week, double-blind, parallel-group trail in which a total of 195 type 2 diabetic patien...

journal_title：European journal of clinical pharmacology

authors： Landgraf R,Bilo HJ,Müller PG

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVES:To investigate the risk factors for noncompliance in elderly home-care recipients; and to evaluate to what extent regular home visits and drug counseling by a pharmacist contribute to compliance. SUBJECTS:One hundred and sixty-three elderly home-care recipients aged 62 years and over took part in this study...

journal_title：European journal of clinical pharmacology

authors： Okuno J,Yanagi H,Tomura S,Oka M,Hara S,Hirano C,Tsuchiya S

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVES:To determine whether patients with idiopathic systemic lupus erythematosus (SLE) are associated with impaired CYP2D6 activity and to gain insight into whether there is an association between particular CYP2D6 genotypes and susceptibility to SLE, and whether CYP2D6 polymorphism is linked to any specific clini...

journal_title：European journal of clinical pharmacology

authors： Kortunay S,Bozkurt A,Bathum L,Basci NE,Calgüneri M,Brøsen K,Kayaalp SO

更新日期：1999-03-01 00:00:00